Dasavatharam

The film starts with Rangaraja Nambi (Kamal Hassan), Vaishnavite, opposes the removal of Lord Vishnu's idol by King Kulothunga Chozhan (Napoleon), who is a strong believer of Shiva. Nambi is punished and thrown into the deep sea tied to the idol. His wife Kothai (Asin) also dies. Then the story starts by Dr Govind (Kamal) discovers a deadly virus, which catches the attention of the government including President George Bush (Kamal). Govind Boss tries to sell to the enemies and how Goving protects he virus going to the wrong hands .

Dr Govind is pursued by a former CIA agent-turned-mercenary Keith Fletcher (Kamal) and his Tamil interpreter (Mallika Sherawat). Balram Naidu (Kamal), the Telugu speaking RAW chief chases Dr oving thinking he is bad guy, a Chinese martial arts teacher (Kamal) thirsting to take revenge on Fletcher, Vincent Poovarahan (Kamal) a Dalit activist , Krishnaveni Patti (Kamal), Khalifullah Khan (Kamal) and a Punjabi pop singer Avatar Singh(Kamal). Andal, a Brahmin girl, is also unwittingly drawn into a long chase. At the end Tsunami scene is been included.